The Formula: Engineered with Clinically-Researched Ingredients

Zynamite® is a patented botanical extract derived from mango leaf, developed as a sustainable, crash-free alternative to caffeine. It works by activating similar neurological pathways to caffeine, including adenosine antagonism and catecholamine release, but with a smoother, more regulated activation curve that doesn't spike the sympathetic system. Supported by 9 human trials, 8 publications, and 3 patents, Zynamite® has been clinically shown to improve mental performance, physical power output, decision-making speed, and post-exertion recovery. In PREWRK, it pairs with Coffeine® and Cognizin® to create a triple-layered activation system that builds gradually and sustains rather than spikes.

Cognizin® is a patented, highly bioavailable form of citicoline, a compound your brain uses to synthesise phosphatidylcholine, a critical building block of neural membranes. More importantly for workday performance, citicoline is a direct precursor to acetylcholine, the neurotransmitter most closely associated with focused, deliberate attention and executive function. Multiple double-blind, placebo-controlled trials demonstrate improvements in sustained attention, working memory, and brain energy metabolism in healthy adults. In PREWRK, Cognizin® pairs with NALT (a dopamine precursor) to support both the calm attention channel and the motivational drive channel simultaneously, which is precisely what a regulated workday requires.

TheaGreen® is a branded, naturally derived L-theanine extract from green tea, standardised for purity and potency. L-theanine promotes alpha-wave brain activity, the brain state associated with wakeful relaxation and creative flow, and is clinically shown to reduce anxiety and mental tension without causing drowsiness. Its most well-established role is in caffeine synergy: L-theanine attenuates the jitteriness and cardiovascular stress response of caffeine while preserving and extending its cognitive benefits. In PREWRK, TheaGreen® works in parallel with Coffeine® and Zynamite® to ensure the activation layer doesn't tip into overstimulation, keeping the sympathetic response calibrated.

Coffeine® is a patented natural caffeine extract derived from coffee beans, gluten-free, non-GMO, and vegan-certified. It delivers the same adenosine-blocking alertness mechanism as synthetic caffeine, but with a cleaner manufacturing process and verified traceability. In PREWRK, Coffeine® is intentionally used as part of a three-component activation system alongside Zynamite® and TheaGreen®, rather than as the dominant driver. This means the dose can be kept within the range associated with clean alertness and improved reaction time, without crossing into the territory that activates the HPA stress axis. The result is smooth, reliable morning ignition, not a sympathetic spike.

Batch 1 contains creatine monohydrate. From Batch 2, this upgrades to Creatine+, a premium creatine monohydrate selected for purity, solubility, and smooth dispersibility. Creatine is most commonly associated with muscular power, but it's equally important in the brain, where it supports ATP regeneration, the cellular energy system that powers cognitive demand. Research shows that creatine supplementation can support working memory, processing speed, and resistance to mental fatigue, particularly under high-demand or sleep-deprived conditions. In PREWRK, creatine is the brain fuel layer, helping maintain the energy baseline needed for sustained cognitive output across a full workday.

CocoMineral® is a branded powdered coconut water extract, naturally rich in potassium, magnesium, and trace electrolytes. Electrolyte balance is foundational to nervous system function: nerve conduction, neurotransmitter release, and membrane potential all depend on correctly regulated mineral concentrations in and around cells. In PREWRK, CocoMineral® forms the base of the hydration and electrolyte system, providing broad-spectrum mineral support that synergises with Potassium Citrate and Pink Himalayan Salt for full-spectrum coverage. Cognitive decline in the afternoon is often partly dehydration-driven; this layer addresses that quietly.

Performelon® is a branded watermelon powder naturally high in L-citrulline, lycopene, and beta-carotene. L-citrulline is a precursor to arginine, which in turn drives nitric oxide (NO) production — a key regulator of vascular tone and blood flow throughout the body and brain. Enhanced cerebral blood flow directly supports cognitive performance by improving oxygen and nutrient delivery to active neural tissue. In PREWRK, Performelon® contributes to the blood-flow support layer — working alongside the hydration system to ensure the brain is both well-supplied and well-regulated.

BioPerine® is a patented piperine extract from black pepper, included in PREWRK not for its own direct cognitive effects, but for its well-established ability to enhance the absorption of other compounds. Clinical studies show BioPerine® increases the bioavailability of specific nutrients by inhibiting metabolic enzymes and slowing intestinal transit, meaning more of each active compound reaches the bloodstream and brain. In a formula with this many precise clinical doses, absorption efficiency is not a footnote. It's critical. BioPerine® ensures the formula you read on the label is the formula your body actually receives.

Neuroplasticity support, the long-game ingredient for cognitive resilience and mood. Derived from Hericium erinaceus, Lion's Mane contains hericenones and erinacines, two classes of bioactive compounds shown to stimulate Nerve Growth Factor (NGF) synthesis. NGF is critical for the growth, maintenance, and survival of neurons, making Lion's Mane the only ingredient in PREWRK that actively supports the brain's capacity for neuroplasticity and long-term adaptation. Recent human trials have demonstrated improvements in cognitive function, memory, and mood in healthy adults. In PREWRK, Lion's Mane is the long-term layer. While other ingredients support today's performance, this one supports your brain's resilience over time. PREWRK uses a high-potency 50% polysaccharide extract for consistent bioactivity.

Rhodiola rosea is a clinically well-studied adaptogen used for centuries under the name "golden root" in Scandinavian and Siberian traditions. Its primary mechanism is HPA axis modulation, helping regulate the cortisol and adrenaline response under psychological and physical stress without sedation. Clinical trials show Rhodiola can support fatigue resistance, cognitive performance under pressure, and mood stability. In PREWRK, it forms the core of the adaptogen layer alongside Panax Ginseng, helping support a more regulated response to stressful workday demands. PREWRK uses a 5% rosavin standardised extract for consistent, reliable potency.

Panax Ginseng has one of the most extensive human research bases of any adaptogenic plant. Its active compounds, ginsenosides, modulate neurotransmitter systems including dopamine, serotonin, and acetylcholine, and have been shown to improve sustained attention, working memory, reaction time, and mental clarity in multiple human trials. In PREWRK, Panax Ginseng complements Rhodiola's stress-buffering role with a more direct performance contribution, supporting attentional endurance and reducing subjective mental fatigue during extended cognitive work. PREWRK uses a 20% ginsenoside standardised extract.

NALT is a highly bioavailable acetylated form of L-tyrosine, an amino acid that serves as the direct precursor to both dopamine and noradrenaline. These catecholamines are the neurochemical basis of motivation, drive, and working memory, and they are the first to deplete under conditions of psychological stress, sleep restriction, or heavy cognitive load. Research shows NALT maintains cognitive performance and working memory capacity under multitasking conditions and stress, precisely the conditions of a demanding workday. In PREWRK, NALT pairs with Cognizin® to ensure both the cholinergic (attention) and dopaminergic (drive) systems are supported simultaneously.

Taurine is a conditionally essential amino acid involved in osmoregulation, neurotransmission, and neuroprotection. Its primary relevance in PREWRK is its interaction with GABAergic and dopaminergic systems, supporting inhibitory neurotransmission associated with calm, stable alertness without sedation. In practical terms, taurine complements TheaGreen® within the formula's activation layer, helping support a smoother balance between stimulation and calm. Research also points to taurine's role in mitochondrial function and cellular hydration, making it a quietly significant contributor to sustained output.

Magnesium is involved in over 300 enzymatic processes in the human body, including ATP synthesis, neurotransmitter regulation, and muscle relaxation. It plays a direct role in HPA axis regulation. Chronic stress depletes magnesium, and magnesium deficiency amplifies stress reactivity, creating a compounding loop. PREWRK uses a blend of glycinate and malate forms, glycinate for superior absorption and nervous system calm, malate for its role in the citric acid cycle (cellular energy production). Clinical evidence consistently links magnesium to reduced anxiety, improved sleep quality, and balanced neurotransmission. The most chronically under-consumed micronutrient in the modern diet, included here at a meaningful dose.

Potassium is the principal intracellular electrolyte, essential for maintaining the membrane potential that allows neurons to fire and recover. It works in constant balance with sodium to regulate fluid distribution and nerve conduction velocity. Potassium Citrate is the citrate-bound form, which also contributes to alkalising the body's acid-base balance, important for metabolic function during sustained cognitive work. In PREWRK, Potassium Citrate works as part of the full electrolyte system alongside CocoMineral® and Pink Himalayan Salt, supporting the foundational conditions for consistent neural signalling throughout the workday.

L-Serine is a conditionally essential amino acid that serves as a key building block for phosphatidylserine (the primary phospholipid of neuronal membranes), sphingolipids, and several neurotransmitters including glycine and serine-based neuromodulators. It is fundamental to the structural and functional integrity of neurons. Emerging research points to L-Serine's role in mood regulation, cognitive protection under stress, and long-term neuroprotection. In PREWRK, it contributes to the neural foundation layer, supporting the structural conditions that make everything else in the formula more effective.

Sodium is the principal extracellular electrolyte. It governs the electrochemical gradient across neural membranes that makes nerve signal conduction possible. Without adequate sodium, the action potential, the electrical impulse that carries every thought, instruction, and perception, cannot propagate correctly. Pink Himalayan Salt provides natural sodium alongside trace minerals including iron, zinc, and potassium, a cleaner, broader-spectrum option than isolated sodium chloride. In PREWRK, it completes the electrolyte triad with CocoMineral® and Potassium Citrate, ensuring full-spectrum baseline hydration and neural signalling support.

PREWRK's B vitamin complex is formulated entirely in active, methylated forms, not the synthetic versions found in most supplements. Pyridoxal-5-Phosphate (B6 at 357% NRV) directly supports dopamine, serotonin, and GABA synthesis. Methylfolate (B9 at 100% NRV) and Methylcobalamin (B12 at 100% NRV) are the only forms usable by those with MTHFR variants who cannot convert synthetic alternatives. Riboflavin (B2) and Pantothenic Acid (B5) complete the complex, supporting cellular energy production and neurotransmitter metabolism throughout the day. This isn't a token B-complex. Every form and dose was chosen for absorption and bioactivity.

PREWRK's flavour system is built from citric acid derived from natural citrus fermentation, combined with botanical lemon and yuzu extracts for a clean, naturally vibrant flavour profile. Citric acid acts as a pH buffer, stabilising the formula and ensuring consistent taste across batches, while also functioning as a mild antioxidant and supporting mineral absorption at the gut wall. The flavour base is designed to remain stable across the full ingredient stack, so what you taste on day one is what you taste on day 40.

PREWRK is sweetened with a stevia leaf extract derived from Stevia rebaudiana Bertoni, the species with the most extensively studied safety and efficacy profile. Stevia glycosides are 200–300× sweeter than sugar by weight, meaning a very small amount delivers sufficient sweetness without caloric load or impact on blood glucose, important for a formula designed for daily, consistent use. Human trials confirm stevia is well-tolerated, supports metabolic balance, and does not disrupt insulin response. No artificial sweeteners.

Bamboo extract standardised to 75% silica serves a dual function in PREWRK. Practically, high-silica bamboo is one of the most effective natural anti-caking agents available, improving powder flow, preventing clumping, and eliminating the need for synthetic flow aids like silicon dioxide (E551). This keeps the formula clean-label. Biologically, silica is a trace mineral involved in connective tissue integrity, collagen formation, and bone and skin health. In PREWRK, bamboo extract earns its place on both grounds, clean formulation function and genuine trace mineral contribution.